Research

What is Native Collagen?

Native Collagen

1) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127184/

2) Denatured vs. Undenatured: http://www.pnas.org/content/83/19/7443.full.pdf+html


How Does Native Collagen Work?

Oral Tolerance

1) Type II collagen oral tolerance

http://www.ncbi.nlm.nih.gov/pubmed/19697097

1) Antigen-induced, tolerogenic CD11c+,CD11b+ dendritic cells are abundant in Peyer's patches during the induction of oral tolerance to type II collagen and suppress experimental collagen-induced arthritis

http://onlinelibrary.wiley.com/doi/10.1002/art.21647/full

2) Oral Tolerance To Food Proteins

O Pabst1 and A M Mowat2
http://www.nature.com/mi/journal/v5/n3/full/mi20124a.html

http://www.nature.com/mi/journal/v5/n3/pdf/mi20124a.pdf

Clinical Studies

http://www.healingwithnutrition.com/adisease/arthritis/harvardstudy.html


Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.David C. Crowley, Francis C. Lau, Prachi Sharma, Malkanthi Evans, Najla Guthrie, Manashi Bagchi, Debasis Bagchi, Dipak K. Dey, Siba P. Raychaudhuri

Abstract:

Previous studies have shown that undenatured type II collagen (UC-II) is effective in the treatment of rheumatoid arthritis, and preliminary human and animal trials have shown it to be effective in treating osteoarthritis (OA). The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chondroitin (G+C) in the treatment of OA of the knee. The results indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was not observed in G+C treatment group. Specifically, although both treatments reduced the Western Ontario McMaster Osteoarthritis Index (WOMAC) score, treatment with UC-II reduced the WOMAC score by 33% as compared to 14% in G+C treated group after 90 days. Similar results were obtained for visual analog scale (VAS) scores. Although both the treatments reduced the VAS score, UC-II treatment decreased VAS score by 40% after 90 days as compared to 15.4% in G+C treated group. The Lequesne's functional index was used to determine the effect of different treatments on pain during daily activities. Treatment with UC-II reduced Lequesne's functional index score by 20% as compared to 6% in G+C treated group at the end of 90-day treatment. Thus, UC-II treated subjects showed significant enhancement in daily activities suggesting an improvement in their quality of life.

Safety and toxicological evaluation of undenatured type II collagen.
Palma Ann Marone, Francis C. Lau, Ramesh C. Gupta, Manashi Bagchi, and Debasis Bagchi

http://flextonic.fr/img/fichiers/Marone.pdf